As you age, your cells do, too
Cells and the DNA within them accumulate injuries as you age and are therefore less able to carry out certain functions such as correcting damage to DNA, generating new cells, generating energy, and other key roles.
For example, cells derived from the skin and blood of older individuals grow more slowly than young cells when cultured in the laboratory. This can make them more difficult to reprogram into a potential therapeutic bank of personalized stem cells called induced pluripotent stem (iPS) cells. Also the accumulated mutations in older cell’s DNA over time may result in a potential therapeutic bank of iPS cells where the DNA contained within may be less helpful in treating disease than the DNA when you were young.
In addition, blood stem cell transplant has been a therapeutic option for treatment of a variety of bloodborne diseases - including leukemias, lymphomas, SCID and sickle cell. Recent research has demonstrated that the blood stem cells used in those transplants accumulate genetic damage over time that is detectable in your early forties, growing at an increasing rate as you age further. That accumulated damage to the DNA in your blood stem cells may limit the utility of those cells in stem cell transplant. Ultimately the best cells you will have for future potential therapeutic use are the least damaged and aged cells you have today.